Optimize PPI Dosing for Nonvariceal Upper GI Bleeds

You'll get questions about using proton pump inhibitors (PPIs) for NONvariceal upper GI bleeding...due to updated guidelines.

Continue to generally start a PPI before endoscopy for a suspected upper GI bleed. This won't decrease rebleeding risk...but it may lead to fewer interventions during endoscopy.

Guidelines continue to advise using a PPI infusion. But consider using 40 mg IV every 12 hours instead. Mounting evidence suggests intermittent doses seem to work as well as an 8 mg/hr drip.